Publications

Nusse and Clevers, et al. Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Cell, 169 (6), 985-999 (2017)

Clevers, et al. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science, 346 (6205), 1248012 (2014)

Nusse, et al. Three decades of Wnts: a personal perspective on how a scientific field developed, The EMBO Journal (2012)

Clevers and Nusse. Wnt/β-Catenin Signaling and Disease. Cell, 149 (6), 1192-1205 (2012)

Janda, et al. Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signaling. Nature, 545, 234-237 (2017)

Wang, et al. Frizzled Receptors in Development and Disease, Current Topics in Developmental Biology (2016)

Bazan, et al. Structural Architecture and Functional Evolution of Wnts, Developmental Cell (2012)

Janda, et al. Structural basis of Wnt recognition by Frizzled. Science, 337 (6090), 59-64 (2012)

MacDonald, et al. Frizzled and LRP5/6 Receptors for Wnt/β-Catenin Signaling, CSH Perspectives (2012)

Nusse, et al. Many Tumors Induced by the Mouse Mammary Tumor Virus Contain a Provirus Integrated in the Same Region of the Host Genome, Cell (1982)

Post, et al., Design principles and therapeutic applications of novel synthetic WNT signaling agonists, iScience, 27:6, 109928 (2024)

Sampathkumar, et al., Targeted protein degradation systems to enhance Wnt signaling, eLife, 13:RP93908 (2024)

Patel, et al. A Wnt mimetic with broad spectrum FZD-specificity decreases fibrosis and improves function in a pulmonary damage model, 25:153, Respiratory Research (2024)

Chen, et al. Effects of Fc glycosylation on the activity of WNT mimetic agonistic antibodies, 7:88, Antibody Therapeutics (2024)

Chen, et al. BRAIDing receptors for cell-specific targeting, 12:RP90221, eLife (2024)

Post, et al., Novel Frizzled-specific antibody-based Wnt mimetics and Wnt superagonists selectivity activate WNT/β-catenin signaling in target tissues, Cell Chem. Biol., 30 (8), 976-986, E5 (2023)

Ding, et al., Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice, Nat Commun, 14, 2947 (2023)

Nguyen, et al., Selective Activation of the Wnt-Signaling Pathway as a Novel Therapy for the Treatment of Diabetic Retinopathy and Other Retinal Vascular Diseases, Pharmaceutics 2022, 14(11), 2476 (2022)

Nguyen, et al. SZN-413, a FZD4 Agonist, as a Potential Novel Therapeutic for the Treatment of Diabetic Retinopathy. Translational Vision Science & Technology 11, 19 (2022)

Xie, et al. Robust Colonic Epithelial Regeneration and Amelioration of Colitis via FZD-Specific Activation of Wnt Signaling. Cellular and Molecular Gastroenterology and Hepatology, 14, 435-464 (2022)

Fowler, et al. Development of selective bispecific Wnt mimetics for bone loss and repair, Nature Communications (2021)

Zhang, et al. Tissue-targeted R-spondin mimetics for liver regeneration. Sci Rep, 10(1):13951 (2020)

Chen et al. Development of Potent, Selective Surrogate WNT Molecules and Their Application in Defining Frizzled Requirements. Cell Chemical Biology, Online, (2020)