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Publications

Our publications focus on research related to potential of the Wnt pathway to address critical drivers of disease.

June 21, 2024 | iScience, 27:6, 109928 (2024)
Design principles and therapeutic applications of novel synthetic WNT signaling agonists
June 7, 2024 | eLife, 13:RP93908 (2024)
Targeted protein degradation systems to enhance Wnt signaling
April 2, 2024 | 25:153, Respiratory Research (2024)
A WNT mimetic with broad spectrum FZD-specificity decreases fibrosis and improves function in a pulmonary damage model
January 9, 2024 | 12:RP90221, eLife (2024)
BRAIDing receptors for cell-specific targeting
January 1, 2024 | 7:88, Antibody Therapeutics (2024)
Effects of Fc glycosylation on the activity of WNT mimetic agonistic antibodies
August 17, 2023 | Cell Chem. Biol., 30 (8), 976-986, E5 (2023)
Novel Frizzled-specific antibody-based Wnt mimetics and Wnt superagonists selectively activate WNT/β-catenin signaling in target tissues
June 2, 2023 | Nat Commmun, 14, 2947 (2023)
Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice
September 28, 2022 | Pharmaceutics 2022, 14(11), 2476 (2022)
Selective Activation of the Wnt-Signaling Pathway as a Novel Therapy for the Treatment of Diabetic Retinopathy and Other Retinal Vascular Diseases
September 2, 2022 | Translational Vision Science & Technology 11, 19 (2022)
SZN-413, a FZD4 Agonist, as a Potential Novel Therapeutic for the Treatment of Diabetic Retinopathy
January 1, 2022 | Cellular and Molecular Gastroenterology and Hepatology, 14, 435-464 (2022)
Robust Colonic Epithelial Regeneration and Amelioration of Colitis via FZD-Specific Activation of Wnt Signaling
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